Nanotechnology in Dentistry: Current Applications, Challenges, and Future Perspectives: A Narrative Review
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Abstract
Nanotechnology has emerged as a transformative force in modern dentistry, offering novel solutions for prevention, diagnosis, restoration, and regeneration. This review synthesizes recent advances in nanomaterials and nanosystems applied across dental specialities, restorative dentistry, endodontics, periodontics, prosthodontics, implantology, oral surgery, and diagnostics. Important innovations include antimicrobial and self-healing resin composites, nano-enabled implant surface modifications, nano-drug delivery, and quantum-dot-based imaging. Key challenges are toxicity, biocompatibility, regulatory barriers, high manufacturing costs, and limited long-term clinical evidence. Nanotechnology holds significant clinical potential in dentistry; however, its successful translation into safe, effective, and widely accessible treatments requires rigorous translational and clinical trials, strict ethical oversight, and scalable manufacturing processes.
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This work is licensed under a Creative Commons Attribution 4.0 International License.
This work is licensed under a Creative Commons Attribution 4.0 International License.
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1. Pavanello L, Cortês IT, de Carvalho RDP, Picolo MZD, Cavalli V, Silva LTS, Boaro LCC, Prokopovich P, Cogo-Müller K. Physicochemical and biological properties of dental materials and formulations with silica nanoparticles: A narrative review. Dent Mater. 2024;40(11):1729-1741. https://doi.org/10.1016/j.dental.2024.07.028.
2. Tomer AK, Gupta R, George M, Saurabh S, Reddy APK, Saxena P, et al. Nanorobotics: The New Face of Nano Dentistry. Int J Recent Advances Multidisciplinary Topics. 2023;4(2):4-6.
3. Javed Muhammad Qasim, Ali Ahmed. A narrative review on applications of nanotechnology in modern endodontics. Saudi Endod J. 2025;15(1):1-8. https://doi.org/10.4103/sej.sej_103_24
4. Dipalma G, Inchingolo AD, Guglielmo M, Morolla R, Palumbo I, Riccaldo L, Mancini A, Palermo A, Malcangi G, Inchingolo AM, Inchingolo F. Nanotechnology and Its Application in Dentistry: A Systematic Review of Recent Advances and Innovations. J Clin Med. 2024;13(17):5268. https://doi.org/10.3390/jcm13175268.
5. Elmarsafy SM. A Comprehensive Narrative Review of Nanomaterial Applications in Restorative Dentistry: Demineralization Inhibition and Remineralization Applications (Part I). Cureus. 2024;16(4):e58544. https://doi.org/10.7759/cureus.58544.
6. Priyadarsini S, Mukherjee S, Mishra M. Nanoparticles used in dentistry: A review. J Oral Biol Craniofac Res. 2018;8(1):58-67. https://doi.org/10.1016/j.jobcr.2017.12.004.
7. Malik S, Waheed Y. Emerging Applications of Nanotechnology in Dentistry. Dent J (Basel). 2023;11(11):266. https://doi.org/10.3390/dj11110266.
8. Alluhaidan T, Garcia IM, Alexis M, Qaw M, Collares FM, Williams MA, Melo MAS. Unlocking tiny titans: 360 view of the quantum dots nanotechnology for dental applications. Front Dent Med. 2025;6:1503057. https://doi.org/10.3389/fdmed.2025.1503057.
9. Zhang X, Zhang J, Zhang T, Yao S, Wang Z, Zhou C, Wu J. Novel low-shrinkage dental resin containing microcapsules with antibacterial and self-healing properties. J Mech Behav Biomed Mater. 2023;148:106212. https://doi.org/10.1016/j.jmbbm.2023.106212.
10. Deshpande AS, Daddanala A, Kaur M, Chahen NA, Patel M, Tummeti N. Nanotechnology in dentistry: Bridging science and practice. Bioinformation. 2025;21(3):522-528. https://doi.org/10.6026/973206300210522.
11. Cheng L, Zhang K, Weir MD, Melo MA, Zhou X, Xu HH. Nanotechnology strategies for antibacterial and remineralizing composites and adhesives to tackle dental caries. Nanomedicine (Lond). 2015;10(4):627-41. https://doi.org/10.2217/nnm.14.191.
12. Raura N, Garg A, Arora A, Roma M. Nanoparticle technology and its implications in endodontics: a review. Biomater Res. 2020;24(1):21. https://doi.org/10.1186/s40824-020-00198-z.
13. Wong J, Zou T, Lee AHC, Zhang C. The Potential Translational Applications of Nanoparticles in Endodontics. Int J Nanomedicine. 2021;16:2087-2106. https://doi.org/10.2147/IJN.S293518.
14. Agrawal R, Bajaj P, Shirbhate U, Reche A, Pahade A, Barhate A. Clinical Implications of Nanosciences in Dentistry and Periodontics: A Narrative Review. Cureus. 2023;15(11):e48593. https://doi.org/10.7759/cureus.48593.
15. Gunasekaran M, Sharma S, Lakshmiprasanna K, Rashid S, Madale A, Veldanda M, Renuka. A Smile for the Future: Nanotechnology Impact on Aesthetics, Durability, and Functionality in Prosthodontics. J Pharm Bioallied Sci. 2024;16 (Suppl 4): S3494-S3496. https://doi.org/10.4103/jpbs.jpbs_968_24.
16. Lavenus S, Louarn G, Layrolle P. Nanotechnology and dental implants. Int J Biomater. 2010;2010:915327. https://doi.org/10.1155/2010/915327.
17. Zinger A, Adir O, Alper M, Simon A, Poley M, Tzror C, Yaari Z, Krayem M, Kasten S, Nawy G, Herman A, Nir Y, Akrish S, Klein T, Shainsky-Roitman J, Hershkovitz D, Schroeder A. Proteolytic Nanoparticles Replace a Surgical Blade by Controllably Remodeling the Oral Connective Tissue. ACS Nano. 2018;12(2):1482-1490 https://doi.org/10.1021/acsnano.7b07983.
18. Calixto G, Bernegossi J, Fonseca-Santos B, Chorilli M. Nanotechnology-based drug delivery systems for treatment of oral cancer: a review. Int J Nanomedicine. 2014;9:3719–3735. https://doi.org/10.2147/IJN.S61670.
19. Chen XJ, Zhang XQ, Liu Q, Zhang J, Zhou G. Nanotechnology: a promising method for oral cancer detection and diagnosis. J Nanobiotechnology. 2018;16(1):52. https://doi.org/10.1186/s12951-018-0378-6.
20. Chandki R, Kala M, Kumar KN, Brigit B, Banthia P, Banthia R. 'Nanodentistry': Exploring the beauty of miniature. J Clin Exp Dent. 2012;4(2):e119-24. https://doi.org/10.4317/jced.50720.
21. Vasiliu S, Racovita S, Gugoasa IA, Lungan MA, Popa M, Desbrieres J. The Benefits of Smart Nanoparticles in Dental Applications. Int J Mol Sci. 2021;22(5):2585. https://doi.org/10.3390/ijms22052585.
22. Uskoković V, Bertassoni LE. Nanotechnology in Dental Sciences: Moving towards a Finer Way of Doing Dentistry. Materials (Basel). 2010;3(3):1674-1691. https://doi.org/10.3390/ma3031674.
23. Abou Neel EA, Bozec L, Perez RA, Kim HW, Knowles JC. Nanotechnology in dentistry: prevention, diagnosis, and therapy. Int J Nanomedicine. 2015;10:6371-94. https://doi.org/10.2147/IJN.S86033.
24. Malik S, Muhammad K, Waheed Y. Emerging Applications of Nanotechnology in Healthcare and Medicine. Molecules. 2023;28(18):6624. https://doi.org/10.3390/molecules28186624.
25. Jiang Z, Javed MU, Tang X, Qu S, Huang D, Guo B. Smart biomaterials in dentistry: A review on the role of cellulose and other biological macromolecules in infection control. Int J Biol Macromol. 2025;327(Pt 1):147293. https://doi.org/10.1016/j.ijbiomac.2025.147293.
26. Dakhale R, Paul P, Achanta A, Ahuja KP, Meshram M. Nanotechnology Innovations Transforming Oral Health Care and Dentistry: A Review. Cureus. 2023;15(10):e46423. https://doi.org/10.7759/cureus.46423.
27. Abdolahinia ED, Golestani S, Seif S, Afra N, Aflatoonian K, Jalalian A, Valizadeh N, Abdollahinia ED. A review of the therapeutic potential of dental stem cells as scaffold-free models for tissue engineering applications. Tissue Cell. 2024;86:102281. https://doi.org/10.1016/j.tice.2023.102281.
28. Liu TY, Lee KH, Mukundan A, Karmakar R, Dhiman H, Wang HC. AI in Dentistry: Innovations, Ethical Considerations, and Integration Barriers. Bioengineering (Basel). 2025;12(9):928. https://doi.org/10.3390/bioengineering12090928.
29. Farzin MA, Naghib SM, Rabiee N. Smart biosensors with self-healing materials. J Mater Chem B. 2025;13(29):8653-8682. https://doi.org/10.1039/d5tb01139f.
30. Habeeb Rahuman HB, Dhandapani R, Narayanan S, Palanivel V, Paramasivam R, Subbarayalu R, Thangavelu S, Muthupandian S. Medicinal plants mediated the green synthesis of silver nanoparticles and their biomedical applications. IET Nanobiotechnol. 2022;16(4):115-144. https://doi.org/10.1049/nbt2.12078.
31. Padovani GC, Feitosa VP, Sauro S, Tay FR, Durán G, Paula AJ, Durán N. Advances in Dental Materials through Nanotechnology: Facts, Perspectives and Toxicological Aspects. Trends Biotechnol. 2015;33(11):621-636. https://doi.org/10.1016/j.tibtech.2015.09.005.
32. Cheng HW, Tsao HY, Chiang CS, Chen SY. Advances in Magnetic Nanoparticle-Mediated Cancer Immune-Theranostics. Adv Healthc Mater. 2021;10(1):e2001451. https://doi.org/10.1002/adhm.202001451